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Bowel cancer genes may triple disease risk

Date: 17/12/2007 09:24:23

British researchers have identified two common genetic variants that appear to triple a person's risk of bowel cancer.

A report in Nature Genetics reveals that two areas near specific genes strongly influence bowel cancer risk and up to a third of cases of the disease are thought to be linked to these high-risk variants.

Professor Richard Houlston, joint lead researcher at the Institute of Cancer Research, commented: "This is an exciting development in our understanding of how bowel cancer develops, a disease which kills more than 16,000 people in the UK each year.

"By pinpointing more genes which increase an individual's risk of bowel cancer we ultimately hope to improve diagnosis and treatment of this cancer."

The study was funded by Cancer Research UK and the charity's director of cancer information, Dr Lesley Walker, revealed that a series of genome-wide studies is being launched to look for genes influencing lung and ovarian cancer risk.

"Discoveries like this will improve our understanding of cancer and help us to develop targeted screening and treatment for people at increased risk of the disease," the expert added.


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